Abstract: IPCC launched the special report of “Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation” (SREX), of which impacts on human systems is one of the most important contents. This paper introduces the main assessment results. Extreme impacts can result from extreme weather and climate events, but can also occur without extreme events. The severity of the impacts of extreme and non-extreme weather and climate events depends strongly on the level of exposure and vulnerability to these events. Settlement patterns, urbanization, and changes in socioeconomic status have all influenced observed trends in vulnerability and exposure to climate extremes. Coastal settlements are exposed and vulnerable to climate extremes in both developed and developing countries, such as in small island states and Asian megadeltas. Vulnerable populations also include refugees, internally displaced people, and those living in marginal areas. Extreme events will have greater impacts on sectors with close links to climate, such as water, agriculture and food security, health, and tourism.