Abstract: First, the U.S. research evolution on climate change is retrospected, the background of U.S. Climate Change Science Program (USCCSP) is analyzed, and the strategic goals, research elements and management structure of USCCSP are introduced. Then the key scientific findings, the key messages about global and U.S. climate change, and the synthesis and assessment products of USCCSP are elaborated. And then the future strategic structure of U.S. climate research is summarized in terms of the Evaluating Progress of the U.S. Climate Change Science Program and Restructuring Federal Climate Research to Meet the Challenges of Climate Change by National Research Council (NRC). Finally some enlightenments and suggestions abut formulating strategic plans, promoting fundamental research, strengthening modeling innovations, advancing observation and data system development, enhancing scientific assessment and climate service, and speeding up legislation process in China are put out based on sum up of USCCSP.